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If it were a regular season game, this would be one of the biggest matchups of the season, but things are a little different in the preseason. Kansas City really has nothing to play for Saturday, while the 49ers need to turn things around.

Patrick Mahomes and the rest of the Chiefs offense are expected to take to the field to start the game, but they will likely appear in a single series. Kansas City could score in that short time, but this offense won't be explosive in this meeting.

The Chiefs will be looking to establish the race against San Francisco , and the defense needs to act, too. Kansas City was eliminated in the 2020 Super Bowl, and that has left a bad taste in their mouths.

San Francisco will send quarterback Trey Lance onto the field in this game, and he could see a lot of action. Lance was the No. 2 pick in the NFL Draft, and he's likely to be the starting quarterback at some point.

The 49ers were one of the best running back teams in the NFL two seasons ago, but this whole offense struggled during the 2020 season. Injuries played a factor, but there were still too many points left on the board.

Defense is always important when facing the Chiefs , but the 49ers will take a breather by not seeing Mahomes for more than one series. San Francisco does have a great defensive line, and it's one that can hurt up front.

Kansas City has nothing to play in this game, but San Francisco does. So look for the 49ers to take control of this game and win.

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